国奥源成果已实现多学科领域转化与应用






创建以干细胞再生医学为核心大数据分析与成果共享网络

国奥源科学家首次在国际上提出了“亚全能干细胞学说”和“间充质干细胞系统”概念,并从15年前至今持续开展对其的研究与学说验证,迄今累计发表中英文论文280余篇,其中被SCI收录的英文论文149篇,被《Nature》等杂志他引2400余次。以SCIE数据库检索2003-2012年世界各国科学家发表的间充质干细胞(MSC)论文数量,赵春华教授领导的实验室以通讯作者发表63篇SCI 论文位居榜首。(见下图统计)

 

团队所发表的论文涵盖了干细胞基础特性研究、自我复制与多胚层分化机制、分子调控机制、干细胞免疫调节功能及其作用机制、各类疾病动物模型的干细胞治疗临床前研究及其再生修复机制、干细胞治疗临床试验、干细胞体内再生修复功能机制、干细胞表观遗传学特征、干细胞诱导分化工艺等几乎有关成体干细胞科研的各个方面,为团队后期的干细胞产业化开发提供了大量技术储备和应用对象。国奥源发表的SCI英文论文列表如下(受篇幅限制,中文论文未列入):

 

PUBLICATIONCorresponding Author

1.      Liu X, Ren S, Ge C, Cheng K, Zenke M, Keating A, Zhao RC. Sca-1+Lin-CD117- Mesenchymal Stem/Stromal Cells Induce the Generation of Novel IRF8-Controlled Regulatory Dendritic Cells through Notch-RBP-J Signaling. J Immunol. 2015 May 1;194(9):4298-308. doi: 10.4049/jimmunol.1402641. Epub 2015 Mar 30.

2.      Liu X, Ren S, Qu X, Ge C, Cheng K, Zhao RC. Mesenchymal stem cells inhibit Th17 cells differentiation via IFN-γ-mediated SOCS3 activation. Immunol Res. 2015 Mar;61(3):219-29. doi: 10.1007/s12026-014-8612-2.

3.      Wang X, Qin J, Zhao RC, Zenke M. Reduced immunogenicity of induced pluripotent stem cells derived from Sertoli cells. PLoS One. 2014 Aug 28;9(8):e106110. doi: 10.1371/journal.pone.0106110. eCollection 2014.

4.      Sun Z, Meng C, Wang S, Zhou N, Guan M, Bai C, Lu S, Han Q, Zhao RC. MicroRNA-1246 enhances migration and invasion through CADM1 in hepatocellular carcinoma. BMC Cancer. 2014 Aug 27;14:616. doi: 10.1186/1471-2407-14-616.

5.      Qin J, Sontag S, Lin Q, Mitzka S, Leisten I, Schneider RK, Wang X, Jauch A, Peitz M, Brüstle O, Wagner W, Zhao RC, Zenke M. Cell Fusion Enhances Mesendodermal Differentiation of Human Induced Pluripotent Stem Cells. Stem Cells Dev. 2014 Jul 8. [Epub ahead of print]

6.      Wang L, Han Q, Chen H, Wang K, Shan GL, Kong F, Yang YJ, Li YZ, Zhang X, Dong F, Wang Q, Xu D, Hu ZJ, Wang SH, Keating A, Bi YL, Zhang FC, Zhao RC. Allogeneic Bone Marrow Mesenchymal Stem Cell Transplantation in Patients with UDCA-Resistant Primary Biliary Cirrhosis. Stem Cells Dev. 2014 Oct 15;23(20):2482-9. doi: 10.1089/scd.2013.0500. Epub 2014 Jul 16.

7.      Li T, Li H, Li T, Fan J, Zhao RC, Weng X. MicroRNA expression profile of dexamethasone-induced human bone marrow-derived mesenchymal stem cells during osteogenic differentiation. J Cell Biochem. 2014 Oct;115(10):1683-91. doi: 10.1002/jcb.24831.

8.      Wei J, Li H, Wang S, Li T, Fan J, Liang X, Li J, Han Q, Zhu L, Fan L, Zhao RC. let-7 Enhances Osteogenesis and Bone Formation While Repressing Adipogenesis of Human Stromal/Mesenchymal Stem Cells by Regulating HMGA2. Stem Cells Dev. 2014 Jul 1;23(13):1452-63. doi: 10.1089/scd.2013.0600. Epub 2014 May 22.

9.      Sun Z, Wang S, Zhao RC. the roles of mesenchymal stem cells in tumor inflammatory microenvironment. J Hematol Oncol. 2014 Feb 6;7:14. doi: 10.1186/1756-8722-7-14.

10.   Ge J, Guo L, Wang S, Zhang Y, Cai T, Zhao RC, Wu Y. The size of mesenchymal stem cells is a significant cause of vascular obstructions and stroke. Stem Cell Rev. 2014 Apr;10(2):295-303. doi: 10.1007/s12015-013-9492-x.

11.   Guo L, Ge J, Zhou Y, Wang S, Zhao RC, Wu Y. Three-dimensional spheroid-cultured mesenchymal stem cells devoid of embolism attenuate brain stroke injury after intra-arterial injection. Stem Cells Dev. 2014 May 1;23(9):978-89. doi: 10.1089/scd.2013.0338. Epub 2014 Feb 11.

12.   Feng N, Han Q, Li J, Wang S, Li H, Yao X, Zhao RC. Generation of highly purified neural stem cells from human adipose-derived mesenchymal stem cells by Sox1 activation. Stem Cells Dev. 2014 Mar 1;23(5):515-29. doi: 10.1089/scd.2013.0263. Epub 2014 Jan 20.

13.   Zhang L, Li K, Liu X, Li D, Luo C, Fu B, Cui S, Zhu F, Zhao RC, Chen X. Repeated systemic administration of human adipose-derived stem cells attenuates overt diabetic nephropathy in rats. Stem Cells Dev. 2013 Dec 1;22(23):3074-86. doi: 10.1089/scd.2013.0142.

14.   Lin R, Wang S, Zhao RC. Exosomes from human adipose-derived mesenchymal stem cells promote migration through Wnt signaling pathway in a breast cancer cell model.Mol Cell Biochem. 2013 Nov;383(1-2):13-20. doi: 10.1007/s11010-013-1746-z. Epub 2013 Jun 29.

15.   Sun Z, Han Q, Zhou N, Wang S, Lu S, Bai C, Zhao RC. MicroRNA-9 enhances migration and invasion through KLF17 in hepatocellular carcinoma. Mol Oncol. 2013 Apr 25. doi:pii: S1574-7891(13)00068-9. 10.1016/j.molonc.2013.04.007.

16.   Li H, Li T, Wang S, Wei J, Fan J, Li J, Han Q, Liao L, Shao C, Zhao RC. miR-17-5p and miR-106a are involved in the balance between osteogenic and adipogenic differentiation of adipose-derived mesenchymal stem cells. Stem Cell Res. 2012 Dec 3;10(3):313-324.

17.   Li J, Zhu L, Qu X, Li J, Lin R, Liao L, Wang J, Wang S, Xu Q, Zhao RC. Stepwise differentiation of human adipose derived mesenchymal stem cells towards definitive endoderm and pancreatic progenitor cells by mimicking pancreatic development in vivo. Stem Cells Dev. 2012 Dec 23. [Epub ahead of print]

18.   Mei Y, Bian C, Li J, Du Z, Zhou H, Yang Z, Zhao RC. miR-21 modulates the ERK-MAPK signaling pathway by regulating SPRY2 expression during human mesenchymal stem cell differentiation. J Cell Biochem. 2012 Dec 13. doi: 10.1002/jcb.24479. [Epub ahead of print]

19.   Chen J, Li J, Han Q, Sun Z, Wang J, Wang S, Zhao RC. Enhancer of zeste homolog 2 is overexpressed and contributes to epigenetic inactivation of p21 and phosphatase and tensin homolog in B-cell acute lymphoblastic leukemia. Exp Biol Med (Maywood). 2012 Sep 1;237(9):1110-6.

20.   Xu Q, Wang L, Li H, Han Q, Li J, Qu X, Huang S, Zhao RC. Mesenchymal stem cells play a potential role in regulating the establishment and maintenance of epithelial-mesenchymal transition in MCF7 human breast cancer cells by paracrine and induced autocrine TGF-β. Int J Oncol. 2012 Sep;41(3):959-68.

21.   Liu X, Qu X, Chen Y, Liao L, Cheng K, Shao C, Zenke M, Keating A, Zhao RC. Mesenchymal stem/stromal cells induce the generation of novel IL-10-dependent regulatory dendritic cells by SOCS3 activation. J Immunol. 2012 Aug 1;189(3):1182-92.

22.   Zeng Y, Qu X, Li H, Huang S, Wang S, Xu Q, Lin R, Han Q, Li J, Zhao RC. MicroRNA-100 regulates osteogenic differentiation of human adipose-derived mesenchymal stem cells by targeting BMPR2.FEBS Lett. 2012 Jul 30;586(16):2375-81.

23.   Dou X, Zhang B, Liu R, Li J, Shi D, Lu C, Zhu X, Liao L, Du Z, Zhao RC. Expanding Sca-1(+) mammary stem cell in the presence of oestrogen and growth hormone. Clin Transl Oncol. 2012 Jun;14(6):444-51.

24.   Qu X, Liu X, Cheng K, Yang R, Zhao RC. Mesenchymal stem cells inhibit Th17 cell differentiation by IL-10 secretion. Exp Hematol. 2012 Sep;40(9):761-70.

25.   Wang S, Qu X, Zhao RC. Clinical applications of mesenchymal stem cells. J Hematol Oncol. 2012 Apr 30;5(1):19. [Epub ahead of print]

26.   Huang S, Wang S, Bian C, Yang Z, Zhou H, Zeng Y, Li H, Han Q, Zhao RC. Upregulation of miR-22 Promotes Osteogenic Differentiation and Inhibits Adipogenic Differentiation of Human Adipose Tissue-Derived Mesenchymal Stem Cells by Repressing HDAC6 Protein Expression. Stem Cells Dev. 2012 Sep 1;21(13):2531-40.

27.   Xuqian W, Kanghua L, Weihong Y, Xi Y, Rongping D, Qin H, Fangtian D, Chunhua Zhao R. Intraocular Transplantation of Human Adipose-Derived Mesenchymal Stem Cells in a Rabbit Model of Experimental Retinal Holes. Ophthalmic Res. 2011 Apr 5;46(4):199-207. [Epub ahead of print]

28.   Zhuang Q, Li J, Wu Z, Zhang J, Sun W, Li T, Yan Y, Jiang Y, Zhao RC, Qiu G.. Differential proteome analysis of bone marrow mesenchymal stem cells from adolescent idiopathic scoliosis patients. PLoS One. 2011 Apr 22;6(4):e18834.

29.   Kaiyan Liu, Yuhong Chen, Yang Zeng, Lanping Xu, Daihong Liu, Huan Chen, Xiaohui Zhang, Wei Han, Yu Wang, Ting Zhao, Jing Wang, Jingzhi Wang, Qin Han, Chunhua Zhao, Xiaojun Huang. Coinfusion of Mesenchymal Stromal Cells Facilitates Platelet Recovery Without Increasing Leukemia Recurrence in Haploidentical Hematopoietic Stem Cell Transplantation: A Randomized, Controlled Clinical Study. Stem Cells Dev. 2011 Oct;20(10):1679-85.

30.   Zhu X, Wang L, Zhang B, Li J, Dou X, Zhao RC. TGF-{beta}1 induced PI3K/Akt/NF-KB/MMP9 signaling pathway is activated in Philadelphia chromosome-positive Chronic Myeloid Leukemia hemangioblasts. J Biochem. 2011 Apr;149(4):405-14.

31.   Guo L, Zhao RC, Wu Y. The role of miRNAs in self-renewal and differentiation of mesenchymal stem cells. Exp Hematol. 2011 Jun;39(6):608-16.

32.   Sun Z, Han Q, Zhu Y, Li Z, Chen B, Liao L, Bian C, Li J, Shao C, Zhao RC. NANOG has a role in Mesenchymal stem cells' immunomodulatory effect. Stem Cells Dev. 2011 Sep;20(9):1521-8.

33.   Lu C, Lu S, Liang W, Li J, Dou X, Bian C, Shi D, Liao L, Zhao RC. TAp63α mediates chemotherapeutic agent-induced apoptosis in human bone marrow mesenchymal stem cells. Stem Cells Dev. 2011 Aug;20(8):1319-26.

34.   Li H, Bian C, Liao L, Li J, Zhao RC. miR-17-5p promotes human breast cancer cell migration and invasion through suppression of HBP1. Breast Cancer Res Treat. 2011 Apr;126(3):565-75.

35.   Shi D, Liao L, Zhang B, Liu R, Dou X, Li J, Zhu X, Yu L, Chen D, Zhao RC. Human adipose tissue-derived mesenchymal stem cells facilitate the immunosuppressive effect of cyclosporin A on T lymphocytes through Jagged-1-mediated inhibition of NF-κB signaling. Exp Hematol. 2011 Feb;39(2):214-224.e1.

36.   Lu S, Lu C, Han Q, Li J, Du Z, Liao L, Zhao RC. Adipose-derived mesenchymal stem cells protect PC12 cells from glutamate excitotoxicity-induced apoptosis by upregulation of XIAP through PI3-K/Akt activation. Toxicology. 2011 Jan 11;279(1-3):189-95.

37.   Yang Z, Bian C, Zhou H, Huang S, Wang S, Liao L, Zhao RC. MicroRNA hsa-miR-138 inhibits adipogenic differentiation of human adipose tissue-derived mesenchymal stem cells through EID-1. Stem Cells Dev. 2011 Feb;20(2):259-67.

38.   Li JM, Zhu H, Lu S, Liu Y, Li Q, Ravenscroft P, Xu YF, Huang L, Ma CM, Bezard E, Zhao RC, Wang R, Qin C. Migration and differentiation of human mesenchymal stem cells in the normal rat brain. Neurol Res. 2011 Jan;33(1):84-92.

39.   Du Z, Li J, Wang L, Bian C, Wang Q, Liao L, Dou X, Bian X, Zhao RC. Overexpression of ΔNp63α induces a stem cell phenotype in MCF7 breast carcinoma cell line through the Notch pathway. Cancer Sci. 2010 Nov;101(11):2417-24. doi: 10.1111/j.1349-7006.2010.01700.x.

40.   Yang Z, Li K, Yan X, Dong F, Zhao C. Amelioration of diabetic retinopathy by engrafted human adipose-derived mesenchymal stem cells in streptozotocin diabetic rats. Graefes Arch Clin Exp Ophthalmol. 2010 Oct;248(10):1415-22. Epub 2010 May 2.

41.   Wu Y, Zhao RC, Tredget EE. Concise review: bone marrow-derived stem/progenitor cells in cutaneous repair and regeneration. Stem Cells. 2010 May;28(5):905-15.

42.   Li J, Zhu H, Liu Y, Li Q, Lu S, Feng M, Xu Y, Huang L, Ma C, An Y, Zhao RC, Wang R, Qin C. Human mesenchymal stem cell transplantation protects against cerebral ischemic injury and upregulates interleukin-10 expression in Macaca fascicularis. Brain Res. 2010 Jun 2;1334:65-72. Epub 2010 Mar 28.

43.   Liang W, Lu C, Li J, Yin JQ, Zhao RC. p73alpha regulates the sensitivity of bone marrow mesenchymal stem cells to DNA damage agents. Toxicology. 2010 Mar 30;270(1):49-56. Epub 2010 Jan 25.

44.   Chen B, Hu J, Liao L, Sun Z, Han Q, Song Z, Zhao RC. Flk-1(+) mesenchymal stem cells aggravate collagen-induced arthritis by up-regulating interleukin-6. Clin Exp Immunol. 2010 Mar;159(3):292-302. Epub 2009 Dec 4.

45.   Zhou H, Guo M, Bian C, Sun Z, Yang Z, Zeng Y, Ai H, Zhao RC. Efficacy of Bone Marrow-derived Mesenchymal Stem Cells in the Treatment for Sclerodermatous Chronic Graft-versus-Host Disease: A clinical report of four patients. Biol Blood Marrow Transplant. 2010 Mar;16(3):403-12. Epub 2009 Nov 17.

46.   Li K, Han Q, Yan X, Liao L, Zhao RC. Not a process of simple vicariousness, the differentiation of human adipose-derived mesenchymal stem cells to renal tubular epithelial cells plays an important role in acute kidney injury repairing. Stem Cells Dev. 2010 Aug;19(8):1267-75. Epub 2009 Oct 29.

47.   Wang J, Bian C, Liao L, Zhu Y, Li J, Zeng L, Zhao RC. Inhibition of hepatic stellate cells proliferation by mesenchymal stem cells and the possible mechanisms. Hepatol Res. 2009 Dec;39(12):1219-28. Epub 2009 Sep 25.

48.   Guo M, Sun Z, Sun QY, Han Q, Yu CL, Wang DH, Qiao JH, Chen B, Sun WJ, Hu KX, Liu GX, Liu B, Zhao RC, Ai H. A modified haploidentical nonmyeloablative transplantation without T cell depletion for high-risk acute leukemia: successful engraftment and mild GVHD. Biol Blood Marrow Transplant. 2009 Aug;15(8):930-7.

49.   Wang L, Zhao RC. Mesenchymal stem cells targeting the GVHD. Sci China C Life Sci. 2009 Jul;52(7):603-9. Epub 2009 Jul 30.

50.   Wang S, Bian C, Yang Z, Bo Y, Li J, Zeng L, Zhou H, Zhao RC. miR-145 inhibits breast cancer cell growth through RTKN. Int J Oncol. 2009 May;34(5):1461-6.

51.   Zhu Y, Sun Z, Han Q, Liao L, Wang J, Bian C, Li J, Yan X, Liu Y, Shao C, Zhao RC. Human mesenchymal stem cells inhibit cancer cell proliferation by secreting DKK-1. Leukemia. 2009 May;23(5):925-33. Epub 2009 Jan 15.

52.   Bu Y, Lu C, Bian C, Wang J, Li J, Zhang B, Li Z, Brewer G, Zhao RC. Knockdown of Dicer in MCF-7 human breast carcinoma cells results in G1 arrest and increased sensitivity to cisplatin. Oncol Rep. 2009 Jan;21(1):13-7.

53.   Zhang B, Liu R, Shi D, Liu X, Chen Y, Dou X, Zhu X, Lu C, Liang W, Liao L, Zenke M, Zhao RC. Mesenchymal stem cells induce mature dendritic cells into a novel Jagged-2 dependent regulatory dendritic cell population. Blood. 2009 Jan 1;113(1):46-57. Epub 2008 Oct 2.

54.   Wang J, Bian C, Li J, Couch FJ, Wu K, Zhao RC. Poly(ADP-ribose) polymerase-1 down-regulates BRCA2 expression through the BRCA2 promoter. J Biol Chem. 2008 Dec 26;283(52):36249-56. Epub 2008 Nov 5.

55.   Liao L, Zhao RC. An overview of stem cell-based clinical trials in China. Stem Cells Dev. 2008 Aug;17(4):613-8.

56.   Zhao RC, Zhu YS, Shi Y. New hope for cancer treatment: Exploring the distinction between normal adult stem cells and cancer stem cells. Pharmacol Ther. 2008 Jul;119(1):74-82.

57.   Yin JQ, Zhao RC, Morris KV. Profiling microRNA expression with microarrays. Trends Biotechnol. 2008 Feb;26(2):70-6.

58.   Qiao L, Xu Z, Zhao T, Zhao Z, Shi M, Zhao RC, Ye L, Zhang X. Suppression of tumorigenesis by human mesenchymal stem cells in a hepatoma model. Cell Res. 2008 Apr;18(4):500-7.

59.   Chen L, Zhang W, Yue H, Han Q, Chen B, Shi M, Li J, Li B, You S, Shi Y, Zhao RC. Effects of Human Mesenchymal Stem Cells on the Differentiation of Dendritic Cells from CD34(+) Cells. Stem Cells Dev. 2007 Oct;16(5):719-732.

60.   Liu Y, Yan X, Sun Z, Chen B, Han Q, Li J, Zhao RC. Flk-1(+) Adipose-Derived Mesenchymal Stem Cells Differentiate into Skeletal Muscle Satellite Cells and Ameliorate Muscular Dystrophy in MDX Mice. Stem Cells Dev. 2007 Oct;16(5):695-706.

61.   Li B, Shi M, Li J, Zhang H, Chen B, Chen L, Gao W, Giuliani N, Zhao RC. Elevated Tumor Necrosis Factor-alpha Suppresses TAZ Expression and Impairs Osteogenic Potential of Flk-1(+) Mesenchymal Stem Cells in Patients with Multiple Myeloma. Stem Cells Dev. 2007 Dec;16(6):921-30.

62.   Yin JQ, Zhao RC. Identifying expression of new small RNAs by microarrays. Methods. 2007 Oct;43(2):123-30.

63.   Yan X, Liu Y, Han Q, Jia M, Liao L, Qi M, Zhao RC. Injured microenvironment directly guides the differentiation of engrafted Flk-1(+) mesenchymal stem cell in lung. Exp Hematol. 2007 Sep;35(9):1466-75.

64.   Shi M, Li J, Liao L, Chen B, Li B, Chen L, Jia H, Zhao RC. Regulation of CXCR4 expression in human mesenchymal stem cells by cytokine treatment: role in homing efficiency in NOD/SCID mice. Haematologica. 2007 Jul;92(7):897-904.

65.   Ma J, Shi M, Li J, Chen B, Wang H, Li B, Hu J, Cao Y, Fang B, Zhao RC. Senescence-unrelated impediment of osteogenesis from Flk1+ bone marrow mesenchymal stem cells induced by total body irradiation and its contribution to long-term bone and hematopoietic injury. Haematologica. 2007 Jul;92(7):889-96.

66.   Han Q, Sun Z, Liu L, Chen B, Cao Y, Li K, Zhao RC. Impairment in immuno-modulatory function of Flk1+CD31-CD34- MSCs from MDS-RA patients. Leuk Res. 2007 Nov;31(11):1469-78.

67.   Liao L, Li L, Zhao RC. Stem cell research in China. Philos Trans R Soc Lond B Biol Sci. 2007 Jun 29;362(1482):1107-12.

68.   Liu L, Sun Z, Chen B, Han Q, Liao L, Jia M, Cao Y, Ma J, Sun Q, Guo M, Liu Z, Ai H, Zhao RC. Ex vivo expansion and in vivo infusion of bone marrow-derived Flk-1+CD31-CD34- mesenchymal stem cells: feasibility and safety from monkey to human. Stem Cells Dev. 2006 Jun;15(3):349-57.

69.   Ren H, Cao Y, Zhao Q, Li J, Zhou C, Liao L, Jia M, Zhao Q, Cai H, Han ZC, Yang R, Chen G, Zhao RC. Proliferation and differentiation of bone marrow stromal cells under hypoxic conditions. Biochem Biophys Res Commun. 2006 Aug 18;347(1):12-21.

70.   Li J, Shi M, Cao Y, Yuan W, Pang T, Li B, Sun Z, Chen L, Zhao RC. Knockdown of hypoxia-inducible factor-1alpha in breast carcinoma MCF-7 cells results in reduced tumor growth and increased sensitivity to methotrexate. Biochem Biophys Res Commun. 2006 Apr 21;342(4):1341-51.

71.   Deng W, Han Q, Liao L, You S, Deng H, Zhao RC. Effects of allogeneic bone marrow-derived mesenchymal stem cells on T and B lymphocytes from BXSB mice. DNA Cell Biol. 2005 Jul;24(7):458-63.

72.   He DN*, Qin H*, Liao LLi NZhu WMYu BJWu XZhao RC.Li JS. Small Intestinal Organoid-Derived SP Cells Contribute to Repair of Irradiation-Induced Skin Injury. Stem Cells Dev. 2005 Jun;14(3):285-91.

73.   Zhao Z, Liao L, Cao Y, Jiang X, Zhao RC. Establishment and properties of fetal dermis-derived mesenchymal stem cell lines: plasticity in vitro and hematopoietic protection in vivo. BMT 2005 Aug;36(4):355-65.

74.   Cao Y, Sun Z, Liao L, Meng Y, Han Q, Zhao RC. Human adipose tissue-derived stem cells differentiate into endothelial cells in vitro and improve postnatal neovascularization in vivo. Biochem Biophys Res Commun. 2005 Jul 1;332(2):370-9.

75.   Deng W*, Han Q*, Liao L, Li C, Ge W, Zhao Z, You S, Deng H, Murad F, Zhao RC. Engrafted bone marrow-derived Flk1+ mesenchymal stem cells regenerate skin tissue. Tissue Eng. 2005 Jan-Feb;11(1-2):110-9.

76.   Fang B*, Zheng C*, Liao L, Han Q, Sun Z, Jiang X, Zhao RC. Identification of human chronic myelogenous leukemia progenitor cells with hemangioblastic characteristics. Blood. 2005 Apr 1;105(7):2733-40.

77.   Chen SL, Fang WW, Qian J, Ye F, Liu YH, Shan SJ, Zhang JJ, Lin S, Liao LM, Zhao RC. Improvement of cardiac function after transplantation of autologous bone marrow mesenchymal stem cells in patients with acute myocardial infarction. Chin Med J (Engl). 2004 Oct;117(10):1443-8.

78.   Deng W*, Han Q*, Liao L, Li C, Ge W, Zhao Z, You S, Deng H, Zhao RC. Allogeneic bone marrow-derived Flk1+Sca-1- mesenchymal stem cells leads to stable mixed chimerism and donor-specific tolerance. Exp Hematol. 2004 Sep;32(9):861-7.

79.   Fang B*, Shi M*, Liao L, Yang S, Liu Y, Zhao RC. Systemic infusion of Flk1+ mesenchymal stem cells ameliorate carbon tetrachloride-induced liver fibrosis in mice. Transplantation. 2004 Jul 15;78(1):83-8.

80.   Chen SL, Fang WW, Ye F, Liu YH, Qian J, Shan SJ, Zhang JJZhao RC. Effect on left ventricular function of intracoronary transplantation of autologous bone marrow mesenchymal stem cell in patients with acute myocardial infarction. Am J Cardiol. 2004 Jul 1;94(1):92-5.

81.   Zhang W, Ge W, Li C, You S, Liao L, Han Q, Deng W, Zhao RC. Effects of mesenchymal stem cells on differentiation, maturation, and function of human monocyte-derived dendritic cells. Stem Cells Dev. 2004 Jun;13(3):263-71.

82.   Zhao RC, Liao L, Han Q. Mechanisms of and perspectives on the mesenchymal stem cell in immunotherapy. J Lab Clin Med. 2004 May;143(5):284-91.

83.   Fang B, Liao L, Shi M, Yang S, Zhao RC. Multipotency of Flk1+CD34- progenitors derived from human fetal bone marrow. J Lab Clin Med. 2004 Apr;143(4):230-40.

84.   Fang BJ, Yu ML, Yang SG, Liao LM, Liu JW, Zhao RC. Effect of O-4-ethoxyl-butyl-berbamine in combination with pegylated liposomal doxorubicin on advanced hepatoma in mice. World J Gastroenterol. 2004 Apr 1;10(7):950-3.

85.   Fang B, Shi M, Liao L, Yang S, Liu Y, Zhao RC. Multiorgan engraftment and multilineage differentiation by human fetal bone marrow Flk1+CD31-CD34- Progenitors. J Hematother Stem Cell Res. 2003 Dec;12(6):603-13.

86.   Guo H, Fang B, Liao L, Zhao Z, Liu J, Chen H, Hsu SH, Cui Q, Zhao RC.  Hemangioblastic characteristics of fetal bone marrow-derived Flk1+CD31-CD34cells. Exp Hematol. 2003 Jul;31(7):650-8.

87.   Hu Y, Liao L, Wang Q, Ma L, Ma G, Jiang X, Zhao RC. Isolation and identification of mesenchymal stem cells from human fetal pancreas. J Lab Clin Med. 2003 May;141(5):342-9.

88.   Li M, You S, Ge W, Ma S, Ma N, Zhao C. Induction of T-cell immunity against leukemia by dendritic cells pulsed with total RNA isolated from leukemia cells. Chin Med J (Engl). 2003 Nov;116(11):1655-61.

89.   Liu Wang, Jian Xu, Li Zeng, Xin Ye, Qihan Wu, Jianfeng Dai, Chaoneng Ji, Shaohua Gu, Zhao RCH, Yi Xie, Yumin Mao. Cloning and characterization of a novel human STAR domain containing cDNA KHDRBS2. 2002, Mol Biol Rep, 29(4):369-375.

90.   Zhao RC. Perspectives: on being a visiting scientist. J Lab Clin Med. 2002 Apr;139(4):192-3.

91.   Guo Hong, Hu Ying, L iao Lianming, Jiang Xueyin, Liu Jiewen, Ma Li, Ma Guanjie, Zhao Zhigang, Yang Shaoguang, Zhao Chunhua. postembryonic subtotipotent stem cells derived from a variety of fetal tissues have multiple differentiation potential and greatly contribute to stem cell plasticity. China J Modern Medicine. 2002 Aug 12(16):1-9.

92.   Zhao RC, Jiang Y, Verfaillie CM. A model of human p210(bcr/ABL)-mediated chronic myelogenous leukemia by transduction of primary normal human CD34+ cells with a BCR/ABL-containing retroviral vector. Blood. 2001 Apr 15;97(8):2406-12.

93.   Zhao RC, McIvor RS, Griffin JD, Verfaillie CM. Gene therapy for chronic myelogenous leukemia (CML): a retroviral vector that renders hematopoietic progenitors methotrexate-resistant and CML progenitors functionally normal and nontumorigenic in vivo. Blood. 1997 Dec 15;90(12):4687-98.

94.   Zhao C, Tang P, Mao N, Zhang S, Fan E, Dong B, Li Q, Du D. Erythropoietin-like activity in vivo of the fusion protein rhIL-6/IL-2 (CH925). Exp Hematol. 1996 Jan;24(1):54-8.

95.   Zhao C, Tang P, Wang J, Mao N, Jiang F, Li X, Liu X, Zhang M, Ren Y, Du D. Overexpression and characterization of recombinant human fusion protein IL-6/IL-2 (CH925). Stem Cells. 1994 May;12(3):339-47.

 

 

PUBLICATIONCooperate Author

96.   Ma X, Chen J, Xu B, Long X, Qin H, Zhao RC, Wang X. Keloid-derived keratinocytes acquire a fibroblast-like appearance and an enhanced invasive capacity in a hypoxic microenvironment in vitro. Int J Mol Med. 2015 May;35(5):1246-56. doi: 10.3892/ijmm.2015.2135. Epub 2015 Mar 13.

97.   Du S, Guan J, Mao G, Liu Y, Ma S, Bao X, Gao J, Feng M, Li G, Ma W, Yang Y, Zhao RC, Wang R. Intra-arterial delivery of human bone marrow mesenchymal stem cells is a safe and effective way to treat cerebral ischemia in rats. Cell Transplant. 2014;23 Suppl 1:S73-82. doi: 10.3727/096368914X685023. Epub 2014 Nov 4.

98.   Wang X, Qin J, Zhao RC, Zenke M. Reduced immunogenicity of induced pluripotent stem cells derived from Sertoli cells. PLoS One. 2014 Aug 28;9(8):e106110. doi: 10.1371/journal.pone.0106110. eCollection 2014.

99.   Feng M, Li Y, Han Q, Bao X, Yang M, Zhu H, Li Q, Wei J, Ma W, Gao H, An Y, Zhao RC, Qin C, Wang R. Preclinical safety evaluation of human mesenchymal stem cell transplantation in cerebrum of nonhuman primates. Int J Toxicol. 2014 Sep;33(5):403-11. doi: 10.1177/1091581814545244. Epub 2014 Aug 17.

100.Guan J, Zhu Z, Zhao RC, Xiao Z, Wu C, Han Q, Chen L, Tong W, Zhang J, Han Q, Gao J, Feng M, Bao X, Dai J, Wang R. Transplantation of human mesenchymal stem cells loaded on collagen scaffolds for the treatment of traumatic brain injury in rats. Biomaterials. 2013 Aug;34(24):5937-46. doi: 10.1016/j.biomaterials.2013.04.047. Epub 2013 May 9.

101.Bao XJ, Liu FY, Lu S, Han Q, Feng M, Wei JJ, Li GL, Zhao RC, Wang RZ. Transplantation of Flk-1+ human bone marrow-derived mesenchymal stem cells promotes behavioral recovery and anti-inflammatory and angiogenesis effects in an intracerebral hemorrhage rat model. Int J Mol Med. 2013 May;31(5):1087-96. doi: 10.3892/ijmm.2013.1290. Epub 2013 Mar 5.

102.Liang W, Xia H, Li J, Zhao RC. Human adipose tissue derived mesenchymal stem cells are resistant to several chemotherapeutic agents. Cytotechnology. 2011 Oct;63(5):523-30. Epub 2011 Jul 15.

103.Wu Y, Zhao RC. The Role of Chemokines in Mesenchymal Stem Cell Homing to Myocardium. Stem Cell Rev. 2011 Jun 25. [Epub ahead of print]  Review.

104.Li Z, Liu C, Xie Z, Song P, Zhao RC, Guo L, Liu Z, Wu Y. Epigenetic dysregulation in mesenchymal stem cell aging and spontaneous differentiation. PLoS One. 2011;6(6):e20526. Epub 2011 Jun 9.

105.Bao X, Feng M, Wei J, Han Q, Zhao H, Li G, Zhu Z, Xing H, An Y, Qin C, Zhao RC, Wang R. Transplantation of Flk-1+ human bone marrow-derived mesenchymal stem cells promotes angiogenesis and neurogenesis after cerebral ischemia in rats. Eur J Neurosci. 2011 Jul;34(1):87-98. doi: 10.1111/j.1460-9568.2011.07733.x. Epub 2011 Jun 21.

106.Fang B, Mai L, Li N, Song Y, Chunhua Zhao R. Imatinib plus Granulocyte Colony-Stimulating Factor in Chronic Myeloid Leukemia Patients Who Have Achieved Partial or Complete Cytogenetic Response while on Imatinib. Case Rep Oncol. 2011 Apr 2;4(1):192-7.

107.Su W, Zhou M, Zheng Y, Fan Y, Wang L, Han Z, Kong D, Zhao RC, Wu JC, Xiang R, Li Z. Bioluminescence reporter gene imaging characterize human embryonic stem cell-derived teratoma formation. J Cell Biochem. 2011 Mar;112(3):840-8. doi: 10.1002/jcb.22982.

108.Guo L, Zhao RC, Wu Y. The role of microRNAs in self-renewal and differentiation of mesenchymal stem cells. Exp Hematol. 2011 Jun;39(6):608-16. Epub 2011 Feb 1. Review.

109.Feng M, Zhu H, Zhu Z, Wei J, Lu S, Li Q, Zhang N, Li G, Li F, Ma W, An Y, Zhao RC, Qin C, Wang R. Serial 18F-FDG PET demonstrates benefit of human mesenchymal stem cells in treatment of intracerebral hematoma: a translational study in a primate model. J Nucl Med. 2011 Jan;52(1):90-7. Epub 2010 Dec 13.

110.Bao X, Wei J, Feng M, Lu S, Li G, Dou W, Ma W, Ma S, An Y, Qin C, Zhao RC, Wang R. Transplantation of human bone marrow-derived mesenchymal stem cells promotes behavioral recovery and endogenous neurogenesis after cerebral ischemia in rats. Brain Res. 2011 Jan 7;1367:103-13. Epub 2010 Oct 23.

111.Fang B, Li Y, Song Y, Li N, Cao Y, Wei X, Lin Q, Zhao RC. Human adipose tissue-derived adult stem cells can lead to multiorgan engraftment. Transplant Proc. 2010 Jun;42(5):1849-56.

112.Fang B, Li N, Song Y, Han Q, Zhao RC. Standard-dose imatinib plus low-dose homoharringtonine and granulocyte colony-stimulating factor is an effective induction therapy for patients with chronic myeloid leukemia in myeloid blast crisis who have failed prior single-agent therapy with imatinib. Ann Hematol. 2010 May 25. [Epub ahead of print]

113.Ma J, Meng Y, Kwiatkowski DJ, Chen X, Peng H, Sun Q, Zha X, Wang F, Wang Y, Jing Y, Zhang S, Chen R, Wang L, Wu E, Cai G, Malinowska-Kolodziej I, Liao Q, Liu Y, Zhao Y, Sun Q, Xu K, Dai J, Han J, Wu L, Zhao RC, Shen H, Zhang H. Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3/p63/Jagged/Notch cascade. J Clin Invest. 2010 Jan;120(1):103-14. doi: 10.1172/JCI37964. Epub 2009 Dec 28.

114.Fang B, Luo S, Song Y, Li N, Li H, Zhao RC. Intermittent dosing of G-CSF to ameliorate carbon tetrachloride-induced liver fibrosis in mice. Toxicology. 2009 Dec 11. [Epub ahead of print]

115.Fang B, Song YP, Li N, Li J, Han Q, Zhao RC. Resolution of refractory chronic autoimmune thrombocytopenic purpura following mesenchymal stem cell transplantation: a case report. Transplant Proc. 2009 Jun;41(5):1827-30.

116.Fang B, Li N, Song Y, Lin Q, Zhao RC. Comparison of human post-embryonic, multipotent stem cells derived from various tissues. Biotechnol Lett. 2009 Mar 21. [Epub ahead of print]

117.Fang B, Song Y, Li N, Li J, Han Q, Zhao RC. Mesenchymal stem cells for the treatment of refractory pure red cell aplasia after major ABO-incompatible hematopoietic stem cell transplantation. Ann Hematol. 2008 Sep 4. [Epub ahead of print]

118.Fang B, Li N, Song Y, Li J, Zhao RC, Ma Y. Cotransplantation of haploidentical mesenchymal stem cells to enhance engraftment of hematopoietic stem cells and to reduce the risk of graft failure in two children with severe aplastic anemia. Pediatr Transplant. 2009 Jun;13(4)499-502. Epub 2008 Jul 30.

119.Fang B, Song Y, Li N, Li J, Zhao RC. Cotransplantation of haploidentical mesenchymal stem cells to reduce the risk of graft failure in a patient with refractory severe aplastic anemia.Acta Haematol. 2008;119(3):162-5. Epub 2008 May 20. No abstract available.

120.Ren G, Zhang L, Zhao X, Xu G, Zhang Y, Roberts AI, Zhao RC, Shi Y. Mesenchymal stem cell-mediated immunosuppression occurs via concerted action of chemokines and nitric oxide. Cell Stem Cell. 2008 Feb 7;2(2):141-50.

121.Xu G, Zhang L, Ren G, Yuan Z, Zhang Y, Zhao RC, Shi Y. Immunosuppressive properties of cloned bone marrow mesenchymal stem cells. Cell Res. 2007 Mar;17(3):240-8.

122.Fang B, Song Y, Liao L, Zhang Y, Zhao RC. Favorable response to human adipose tissue-derived mesenchymal stem cells in steroid-refractory acute graft-versus-host disease.Transplant Proc. 2007 Dec;39(10):3358-62.

123.Fang B, Song Y, Lin Q, Zhang Y, Cao Y, Zhao RC, Ma Y. Human adipose tissue-derived mesenchymal stromal cells as salvage therapy for treatment of severe refractory acute graft-vs.-host disease in two children. Pediatr Transplant. 2007 Nov;11(7):814-7.

124.Fang B, Song Y, Lin Q, Zhang Y, Cao Y, Zhao RC, Ma Y. Human adipose tissue-derived mesenchymal stromal cells as salvage therapy for treatment of severe refractory acute graft-vs.-host disease in two children. Pediatr Transplant. 2007 Nov;11(7):814-7.

125.Fang B, Song Y, Zhao RC, Han Q, Lin Q. Using human adipose tissue-derived mesenchymal stem cells as salvage therapy for hepatic graft-versus-host disease resembling acute hepatitis. Transplant Proc. 2007 Jun;39(5):1710-3.

126.Fang B, Song Y, Zhao RC, Han Q, Cao Y. Treatment of resistant pure red cell aplasia after major abo-incompatible bone marrow transplantation with human adipose tissue-derived mesenchymal stem cells. Am J Hematol. 2007 Aug;82(8):772-3.

127.Fang B, Song Y, Ma J, Zhao RC. Severe Epidermal Necrolysis after Bortezomib Treatment for Multiple Myeloma. Acta Haematol. 2007 May 15;118(2):65-67

128.Fang B, Song Y, Han Z, Wei X, Lin Q, Zhu X, Yang R, Sun J, Tian G, Liu X, Cao G, Shi Y, Nie N, Li D, Zhao RC. Synergistic interactions between 12-0-tetradecanoylphorbol-13-acetate (TPA) and imatinib in patients with chronic myeloid leukemia in blastic phase that is resistant to standard-dose imatinib. Leuk Res. 2007 Oct;31(10):1441-4.

129.Fang B, Song YP, Liao LM, Han Q, Zhao RC. Treatment of severe therapy-resistant acute graft-versus-host disease with human adipose tissue-derived mesenchymal stem cells. Bone Marrow Transplant. 2006 Sep;38(5):389-90.

130.Pan C, Nelson MS, Reyes M, Koodie L, Brazil JJ, Stephenson EJ, Zhao RC, Peters C, Selleck SB, Stringer SE, Gupta P. Functional abnormalities of heparan sulfate in mucopolysaccharidosis-I are associated with defective biologic activity of FGF-2 on human multipotent progenitor cells. Blood. 2005 Sep 15;106(6):1956-64. 

131.Zou X, Wang D, Qiu G, Ji C, Jin F, Wu M, Zheng H, Li X, Sun L, Wang Y, Tang R, Zhao RC, Mao Y. Molecular cloning and characterization of a novel human C4orf13 gene, tentatively a member of the sodium bile acid cotransporter family. Biochem Genet. 2005 Apr;43(3-4):165-73.

132.Ye X, Ji C, Yin G, Tang R, Zeng L, Gu S, Ying K, Xie Y, Zhao RC, Mao Y. Characterization of a human Sec14-like protein cDNA SEC14L3 highly homologous to human SPF/TAP. Mol Biol Rep. 2004 Mar;31(1):59-63.

133.Zhao E, Li Y, Fu X, Zhang JY, Zeng H, Zeng L, Lin Y, Chen J, Yin G, Qian J, Ying K, Xie Y, Zhao RC, Mao YM. Cloning and expression of human GTDC1 gene (glycosyltransferase-like domain containing 1) from human fetal library. DNA Cell Biol. 2004 Mar;23(3):183-7.

134.Ye X, Ji C, Yin G, Tang R, Zeng L, Gu S, Ying K, Xie Y, Zhao RC, Mao Y. Characterization of a human Sec14-like protein cDNA SEC14L3 highly homologous to human SPF/TAP. Mol Biol Rep. 2004 Mar;31(1):59-63.

135.Zhao E, Li J, Xie Y, Jin W, Zhang Z, Chen J, Zeng L, Yin G, Qian J, Wu H, Ying K, Zhao RC, Mao Y. Cloning and identification of a novel human RNPC3 gene that encodes a protein with two RRM domains and is expressed in the cell nucleus. Biochem Genet. 2003 Oct;41(9-10):315-23.

136.Zhao E, Li Y, Fu X, Zeng L, Zeng H, Jin W, Chen J, Yin G, Qian J, Ying K, Xie Y, Zhao RC, Mao Y. Cloning and characterization of human synaptotagmin 10 gene. DNA Seq. 2003 Oct;14(5):393-8.

137.Yin G, Dai J, Ji C, Ni X, Shu G, Ye X, Dai J, Wu Q, Gu S, Xie Y, Zhao RC, Mao Y. Cloning and characterization of the human IFT20 gene. Mol Biol Rep. 2003 Dec;30(4):255-60.

138.Jianfeng Dai, Yi Xie, Qihan Wu, Liu Wang, Gang Yin, Xin Ye, Li Zeng, Jian Xu, Chaoneng Ji, Shaohua Gu, Qingshan Huang, Zhao RCH Yumin Mao. Molecular cloning and characterization of a novel human hydroxysteroid dehydrogenase-like2 (HSDL2) cDNA from fetal brain. Biochemical Genetics. 2003, Jun;41(5-6):165-74.

139.Ni X, Ji C, Cao G, Cheng H, Guo L, Gu S, Ying K, Zhao RC, Mao Y. Molecular cloning and characterization of the protein 4.1O gene, a novel member of the protein 4.1 family with focal expression in ovary. J Hum Genet. 2003;48(2):101-6.

140.Wang L, Xu J, Wu Q, Dai J, Ye X, Zeng L, Ji C, Gu S, Zhao RC, Xie Y, Mao Y. Cloning and characterization of a novel splice variant of the brain-specific protein densin-180. Int J Mol Med. 2003 Feb;11(2):257-60. 

141.Cui Q, Yip HK, Zhao RC, So KF, Harvey AR. Intraocular elevation of cyclic AMP potentiates ciliary neurotrophic factor-induced regeneration of adult rat retinal ganglion cell axons. Molecular and Cellular Neuroscience. 2003:22 49-61.

142.Tan Y, Li G, Zhao RC, Wang J, Zhao H, Xue Y, Han M, Yang C. Expression of sorcin predicts poor outcome in acute myeloid leukemia. Leuk Res 2003 Feb;27(2):125-31.

143.Nakajima H, Zhao RC, Miller JS. The BCR/ABL transgene causes abnormal NK cell differentiation and can be found in circulating NK cells of advanced phase chronic myelogenous leukemia patients. J Immunol 2002;15;168(2):643-50

144.Jiang Y, Zhao RC, Verfaillie CM: Abnormal integrin-mediated regulation of CML CD34+ cell proliferation: BCR/ABL upregulates the cdki p27, which is relocated to the cell cytoplasm and incapable of regulation cdk2 activity. PNAS .2000;97:10538-10543

145.Verfaillie CM, McIvor RS, Zhao RC. Gene therapy for CML. Molecular. Med. Today 1999; 5:359-366

146.Verfaillie CM, Prosper F, Liu J, Weber E, Zhao RC, Bhatia R. “Role of integrins in hematopoiesis”. Hematol Citocinas Inmunoter Ter Cel 1998, 1: 257-270.

147.Verfaillie CM, Hurley R, Lundell B, Zhao RC, et al:  Pathophysiology of CML: Do defects in integrin function contribute to the premature circulation and massive expansion of the BCR/ABL positive clone?  J of Laboratory & Clinical Medicine. 1997; 129:584-91

148.Verfaillie CM, Hurley R, Lundell B, Zhao RC, et al:  Integrin-mediated regulation of hematopoiesis: Do BCR/ABL-induced defects in integrin function underlie the abnormal circulation and proliferation of CML progenitors?  Acta Haematol 1997; 97:40-52

149.Verfaillie CM, Hurley R, Zhao RC, Prosper F, Delforge M, Bhatia R. Pathophysiology of CML: do defects in integrin function contribute to the premature circulation and massive expansion of the BCR/ABL positive clone? J Lab Clin Med. 1997 Jun;129(6):584-91. Review.